DR PRASAD NARAYANAN
Senior Consultant & Director - Medical Oncology, Hemato Oncology & BMT
Karnataka's First Hospital to Offer Life-saving CAR-T Cell Therapy
Learn MoreRevolutionizing Cancer Treatment: CAR-T Cell Therapy in Bangalore.
We provide cutting-edge CAR-T Cell Therapy in Bangalore, utilising advanced the NexCAR 19 treatment by ImmunoAct and expertise to stimulate the patient's immune system and effectively fight cancer. Cytecare is one of the first centers to offer CAR-T Cell Therapy in Karnataka.
Overview
Car-T Cell Therapy
CAR-T Cell therapy, a groundbreaking treatment offered at Cytecare Cancer Hospital in Bangalore, delivers unparalleled benefits in the fight against cancer. By harnessing the body's natural defense system, this innovative therapy stimulates the immune system to specifically target cancer cells, leading to greater clinical efficacy. Unlike targeted agents, CAR-T Cell therapies directly activate the immune system, resulting in remarkable results.
NexCAR19 is a prescription drug developed by ImmunoAct for treating specific relapsed or refractory B-cell cancers ( lymphomas and acute lymphoblastic leukemia). It involves genetically modifying your body’s T-cells in a controlled laboratory setting, and then reinfusing the modified T-cells back to the patient, which are empowered to identify & destroy certain B-cell cancers.
With CAR-T Cell therapy, patients can experience remarkable efficacy, even if they haven't responded to traditional treatments like chemotherapy and radiation . The therapy's success lies in its ability to precisely target cancer cells while preserving healthy cells, minimizing collateral damage. Moreover, patients who undergo CAR-T Cell therapy report sustained periods free from cancer recurrence, unlocking a chance for a significantly improved quality of life.
One of the greatest advantages of NexCAR 19 or CAR-T Cell therapy is its potential for diverse applications. Ongoing research explores its effectiveness in treating various solid tumors, indicating its promising role in revolutionizing cancer treatment across different cancer types. The therapy has shown exceptional outcomes in clinical trials, with notable increases in survival rates among patients. This signifies a transformative shift in cancer treatment and management. Previous treatments were limited to surgery, chemotherapy, and radiotherapy. CAR-T Cell is a type of treatment for waking up the body’s immune system so that our own immune system can act against cancer.
Benefits
Benefits of CAR-T Cell Therapy
CAR-T Cell therapy offers several significant benefits for cancer patients. Let's take a look at some of the key benefits of NexCAR:
- Targeted Treatment: One of the most remarkable benefits of CAR-T Cell therapy is its targeted approach. Unlike traditional treatments such as chemotherapy or radiation, which can harm healthy cells and cancer cells, CAR-T Cell therapy focuses solely on cancerous cells. This targeted attack minimizes damage to healthy tissues, reducing the side effects often associated with traditional cancer treatments.
- Long-lasting remission: CAR-T Cell therapy has shown tremendous effectiveness in treating certain types of cancer. In clinical trials, it has achieved remarkable response rates and even induced complete remission in some patients. These promising results have been particularly notable in patients with certain forms of blood cancers , such as acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). CAR-T Cell therapy has shown the potential to provide long-lasting remissions and significantly improve patient outcomes.
-
Treatment for Relapsed or Refractory Cancers: For patients facing relapsed or refractory cancers, where previous treatments have been unsuccessful, CAR-T Cell therapy offers new hope. It has demonstrated effectiveness in cases where other treatment options have failed. By utilising the patient's own immune cells and genetically modifying them to specifically target cancer cells, CAR-T Cell therapy can overcome the resistance of cancer cells to traditional treatments.
- What type of cancers does NexCAR 19 CAR T-cell therapy treat?
- B-cell Acute Lymphoblastic Leukaemia
- High grade B-lymphomas
- Low grade B-lymphomas
- Reduced Need for Conventional Treatments: CAR-T Cell therapy has the potential to reduce the need for conventional cancer treatments in some cases. Successful CAR-T Cell therapy can lead to extended periods of remission, potentially minimizing the need for ongoing therapies such as chemotherapy or radiation. This reduction in reliance on traditional treatments can greatly improve the quality of life for cancer patients.
- Personalized Approach to Treatment: Each CAR-T Cell therapy treatment is tailored to the individual patient. The patient's own T-Cells are used in the therapy, making it a personalized treatment option. CAR-T Cell therapy takes advantage of the body's natural defense mechanisms by using the patient's immune cells. This personalized approach increases the likelihood of a positive response to treatment and minimizes the risk of rejection or other complications.
Procedure
CAR-T Cell Therapy Procedure
- T-Cell Collection: The CAR-T Cell Therapy procedure begins with collecting T-Cells from the patient's blood. This process, known as leukapheresis, involves removing blood from the patient's body through a needle or catheter. The blood is then passed through a machine that separates the T-Cells from the other components. The remaining blood components are returned to the patient's body while the isolated T-Cells are collected for further processing.
- T-Cell Engineering: Once the T-Cells have been collected, they are sent to the laboratory where they are genetically modified. Scientists introduce a synthetic gene into the T-Cells, enabling them to express a chimeric antigen receptor (CAR) on their surface. This receptor is designed to recognize and bind to a specific antigen present on the cancer cells.
- T-Cell Expansion: After the T-Cells have been genetically modified, they undergo a period of cell culture and expansion. This step involves providing the T-Cells with the necessary growth factors and nutrients to multiply and increase in number. This ensures that a significant amount of CAR-expressing T-Cells are available for treatment.
- CAR-T Cell Infusion: Once a sufficient number of CAR-expressing T-Cells have been produced, they are infused back into the patient's bloodstream. This process is similar to a blood transfusion and is typically administered in a hospital setting. The infused CAR-T Cells then circulate within the patient's body, seeking out and attacking the cancer cells that express the specific antigen recognised by the CAR.
DR MOHANARAJ RAMACHANDRAN
Consultant - Pediatric Oncology and bone marrow transplant
DR (LT COL) MANISH KUMAR
Senior Consultant- Medical Oncology, Hemato-oncology & BMT
WHY CYTECARE
At Cytecare, we promote advanced focused cancer care for each and every individual- a profound approach to individuals and their cancer treatment. We understand and believe that every cancer is different; hence, we practice specialised cancer treatment for each case. Our multidisciplinary cancer specialist team consists of researched cancer care practitioners strongly guided by national and global protocols, making us the best cancer hospital in Bangalore.
Recognized by Indian Association Of Palliative Care
Our Hospital Is NABH Accredited
Designated Center Of Integrated Oncology And Palliative Care
Our Laboratory Is NABH Accredited
Cytecare Cancer Hospital Achiever In Oncology
BLOGS
A detailed insight into everything related to cancer care, cancer symptoms, cancer treatment and mitigation process from the team at Cytecare Cancer Hospitals.
FAQs for CAR-T Cell Therapy
Here are the frequently asked questions about CAR-T Cell Therapy.
CAR-T Cell therapy uses genetically modified T-Cells to target and destroy cancer cells. These engineered cells are designed to recognise specific markers on cancer cells, leading to their destruction.
CAR-T Cell therapy has shown exceptional results in treating certain types of blood cancers, such as B-cell Acute Lymphoblastic Leukaemia, High grade B-lymphomas. Low grade B-lymphomas. Ongoing research is exploring its potential for treating other cancers as well.
CAR-T Cell therapy can have side effects like any medical treatment, including cytokine release syndrome and neurologic toxicities. Our experienced medical team closely monitors patients and takes appropriate measures to manage and minimise these side effects.
The duration of CAR-T Cell therapy can vary depending on the individual and the specific treatment plan. It typically involves multiple stages, including cell collection, genetic modification, and infusion. Our team will provide you with a personalised timeline.
In some cases, CAR-T Cell therapy can be combined with other cancer treatments to maximise the efficacy. Our multidisciplinary team will assess your situation and develop a comprehensive treatment plan.
CAR-T Cell therapy has shown the potential for long-term remission in many patients. However, individual responses can vary. Our dedicated team will closely monitor your progress and support you throughout your journey.
CAR-T Cell therapy has shown promising results in pediatric patients with certain types of blood cancers. However, each case is evaluated individually, taking into consideration the patient's condition and medical history.
Success rates of CAR-T Cell therapy can vary depending on the type and stage of cancer. Clinical trials have shown exceptiona response rates upto > 80%, leading to improved survival outcomes for many patients.